Open Hours

Mon 4pm-10pm
Closed Tuesdays
Wed - Sat 4pm-11pm
Sunday 4pm - 9pm

(716) 825-6200

1816 Clinton Street,
Buffalo NY 14206

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Desi's Pizzeria


Desi’s Pizzeria, founded in 1970 by Dominic Desiderio Sr., was owned and operated by his son and daughter-in-law, Dave and MaryAnn. Still in the Desiderio family, now operated by Dave's Brother and Sister-in-law, Mark and Dorothy. Dominic’s commitment to personalized service and uncompromising quality continues today.

From a humble ham sub to our mouth-watering lasagna, visit us for a friendly hello, and some of the best food in town.

Remember: “At Desi’s quality is the difference that’s always in your flavor.”

Desis Buffalo Pizzeria